Table 2 Differentially methylated probes (DMPs) in first trimester placenta that reach genome-wide significance (P < 9 × 10–8)
From: Sexually dimorphic DNA methylation and gene expression patterns in human first trimester placenta
probeID | Chr:Start | UCSC gene (context) | Relation to UCSC CpG Island | LogFC and direction higher methylation | P-value | FDR | |
|---|---|---|---|---|---|---|---|
cg17612569 | 21: 27,107,221 | GABPA (TSS200); ATP5J (5′UTR, 1stExon, Body) | Island | − 2.066 | Male | 4.58E−28 | 3.41E−22 |
cg13192180 | 17: 65,717,569 | NOL11 (Body) | S_Shelf | − 0.902 | Male | 7.91E−18 | 2.94E−12 |
cg00167275 | 10: 88,854,588 | FAM35A (TSS1500); GLUD1 (5′UTR, 1stExon) | Island | 2.329 | Female | 5.36E−16 | 1.33E−10 |
cg15817705 | 1: 209,406,063 | S_Shore | − 0.468 | Male | 5.33E−14 | 9.91E−09 | |
cg09516963 | 12: 68,042,445 | DYRK2 (TSS200) | Island | 0.783 | Female | 4.41E−12 | 5.49E−07 |
cg09241427 | 11: 70,860,363 | SHANK2 (5′UTR) | 0.473 | Female | 4.43E−12 | 5.49E−07 | |
cg08937153 | 8: 48,504,810 | SPIDR (body) | − 0.602 | Male | 1.55E−11 | 1.65E−06 | |
cg10661558 | 21: 15,443,159 | Island | 0.714 | Female | 7.50E−11 | 6.97E−06 | |
cg00804338 | 13: 114,239,234 | TFDP1 (5′UTR, Body) | 1.629 | Female | 3.48E−10 | 2.87E−05 | |
cg25452172 | 12: 58,162,751 | METTL1 (3′UTR) | N_Shelf | − 0.330 | Male | 5.86E−10 | 4.06E−05 |
cg20374928 | 20: 42,087,910 | SFRS6 (body) | S_Shore | 0.467 | Female | 6.01E−10 | 4.06E−05 |
cg15604132 | 5: 150,285,117 | ZNF300 (TSS1500) | S_Shore | − 1.277 | Male | 1.24E−09 | 7.70E−05 |
cg05994094 | 18: 31,020,806 | C18orf34 (TSS200, TSS1500) | Island | 1.698 | Female | 1.99E−09 | 0.000114 |
cg08580836 | 5: 150,284,448 | ZNF300 (TSS200) | Island | − 1.782 | Male | 2.30E−09 | 0.000122 |
cg09829303 | 7: 134,419,774 | 0.380 | Female | 2.46E−09 | 0.000122 | ||
cg14974262 | 5: 150,284,594 | ZNF300 (TSS200) | Island | −1.412 | Male | 4.76E−09 | 0.000217 |
cg04032578 | 5: 150,284,619 | ZNF300 (TSS200) | Island | − 1.369 | Male | 4.96E−09 | 0.000217 |
cg12777992 | 5: 150,284,634 | ZNF300 (TSS200) | Island | − 1.605 | Male | 5.75E−09 | 0.000237 |
cg21228005 | 5: 150,284,796 | ZNF300 (TSS 1500) | S_Shore | − 2.192 | Male | 6.39E−09 | 0.00025 |
cg18237551 | 5: 150,284,600 | ZNF300 (TSS 1500) | Island | − 1.469 | Male | 7.74E−09 | 0.000288 |
cg17561788 | 22: 20,114,683 | RANBP1 (3′UTR) | N_Shelf | − 0.507 | Male | 1.10E−08 | 0.000387 |
cg12385553 | 22: 17,256,079 | − 0.669 | Male | 1.15E−08 | 0.000387 | ||
cg02343823 | 5: 150,284,419 | ZNF300 (TSS200) | Island | − 1.341 | Male | 1.73E−08 | 0.000558 |
cg07628841 | 2: 27,851,430 | GPN1 (TSS200, TSS1500); CCDC121 (5′UTR, 1st Exon) | 0.748 | Female | 1.90E−08 | 0.000587 | |
cg11291313 | 5: 150,284,530 | ZNF300 (TSS200) | Island | − 1.270 | Male | 2.10E−08 | 0.000626 |
cg09971754 | 16: 89,557,657 | ANKRD11 (TSS1500) | Island | − 0.864 | Male | 2.57E−08 | 0.000736 |
cg13150358 | 2: 51,808,957 | 0.615 | Female | 3.77E−08 | 0.001017 | ||
cg26486466 | 5: 150,284,616 | ZNF300 (TSS200) | Island | − 1.179 | Male | 3.83E−08 | 0.001017 |
cg21161307 | 8: 86,981,879 | − 1.213 | Male | 7.03E−08 | 0.001802 | ||