Fig. 1
From: Gene regulatory networks reveal sex difference in lung adenocarcinoma
Schematic overview of the study. Top box, overview of the approach used to construct individual specific gene regulatory networks with PANDA and LIONESS by integrating information on protein–protein interaction between transcription factors (TFs), TF-gene motif binding, and gene expression data of GTEx healthy lung tissues and TCGA lung adenocarcinoma (LUAD) primary tumor samples from Recount3. Bottom box, overview of the differential targeting analysis and independent datasets for validation