Table 4 Pathway Analysis of Differentially Expressed Proteins in Mouse RPE
From: Quantitative proteomic profiling reveals sexual dimorphism in the retina and RPE of C57BL6 mice
Name | # Molecules | p-value |
|---|---|---|
Top canonical pathways | ||
Calcium signaling | 9 | 2.16E-09 |
Dilated cardiomyopathy signaling pathway | 8 | 2.25E-09 |
Striated muscle contraction | 5 | 2.13E-08 |
Actin cytoskeleton signaling | 8 | 1.00E-07 |
Hepatic fibrosis/hepatic stellate cell activation | 7 | 3.53E-07 |
Upstream regulators | ||
 PHA-666859 | 6 | 1.43E-13 |
 Sesaminol | 7 | 5.93E-12 |
 MAF | 7 | 1.97E-10 |
 Celf1 | 6 | 6.41E-10 |
 MEF2C | 8 | 4.05E-09 |
Name | # Molecules | p-value range |
|---|---|---|
Molecular and cellular functions | ||
 Cellular assembly and organization | 29 | 2.32E-02–2.55E-09 |
 Cellular function and maintenance | 36 | 2.49E-02–2.17E-06 |
 Protein synthesis | 16 | 2.49E-02–2.17E-06 |
 Cellular movement | 23 | 2.21E-02–6.68E-06 |
 Cell-to-cell signaling and interaction | 21 | 2.32E-02–3.29E-05 |
Top DE Proteins Increased in Females vs Male Pool | Top DE Proteins Decreased in Females vs Male Pool |
|---|---|
MYH7B (+1.526) | SERPINA1 (− 2.493) |
CASQ2 (+1.327) | MUG1/MUG2 (− 1.574) |
MYL10 (+1.312) | SERPINA3 (− 1.325) |
CRYGC (+1.308) | LAMC1 (− 1.302) |
MYOZ2 (+1.308) | TTR (− 1.290) |
CRYAA (+1.262) | ACE (− 1.270) |
AMPH (+1.252) | MYH4 (− 1.263) |
 MYL2 (+1.238) | SYNJ1 (− 1.245) |
MB (+1.225) | COL1A1 (− 1.237) |
MYH3 (+1.219) | DSG1 (− 1.225) |