Fig. 1

Spatiotemporally specific expression of sex-biased genes in the human brain. (A) Numbers of sex-biased genes in the 16 regions and four periods. More genes show male-biased expression in all regions in the fetal and adult periods, and more lncRNA genes show male-biased expression in adulthood than in other periods. (B) Numbers of region-specific sex-biased genes in the fetal period. (C) Numbers of period-specific sex-biased genes in the STR region. (D) The enrichment of spatiotemporal-specific sex-biased genes in the subterms of the “neurogenesis” GO term. (E) The enrichment of spatiotemporal-specific sex-biased genes in terms of the “immune response” GO term. In (DE), the dot size indicates the number of subterms