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Table 4 Genes associated with various kidney diseases that show sex dependence

From: Embracing sex-specific differences in engineered kidney models for enhanced biological understanding of kidney function

Gene

Associated disease

References

JAG1, HES1

Diabetic nephropathy (human)

[113]

GAP43, FOXD1, POSTN, EMP2, PTGIS, MPPED2, AKR1C2, PTHLH, ANKRD6, LRRC17, VIM

Chronic kidney disease (human)

[114]

CA9, DGCR5, EGLN3, SLC16A3, SLC5A3, SPAG4, VEGF, SEMA5B, PFKP, PRAME, MUF1, MGC45419, GPR54, FABP7

Clear cell renal cell carcinoma (human)

[115, 116]

Tpbg, RFP, HLA-DQA1, SCNN1B, SLC15A2

X-linked Alport syndrome (Canine)

[30]

VEGFa, LRPAP1, AGTR1, SLC12A1, CUBN, DAO1, KCNJ1, CASR, PTHR1, SLC12A3, FXYD2, KLK6, SCNN1A, SCNN1B, ATP6V1B1, AVPR2, AQP2

Polycystic kidney disease (mouse)

[117]

  1. Genes related to pregnancy (specific to females) and spermatogenesis (specific to males) are highlighted in bold