Fig. 2
From: The Four Core Genotypes mouse model: evaluating the impact of a recently discovered translocation
Chromosomal gene dosage and relative expression levels of X chromosome genes translocated to a C57BL/6J YSry− chromosome. Schemes show sex chromosome and gonadal type in A wildtype female and male mice, B C57BL/6J Four Core Genotypes mice that carry the YSry− translocation, and C XY* mice. X chromosome genes that are duplicated on the YSry− chromosome (FCG model) or the Y* chromosome (XY* model) are shown in blue and yellow boxes, respectively. For each mouse model, the diagram shows sex chromosome and gonadal composition, the X and Y dosage, and expected gene expression levels for the X chromosome genes that are duplicated on the Y chromosome. The designation of “≥” under genotypes with two X chromosomes refers to potential expression of some boxed genes from both X alleles due to escape from X inactivation in specific cell types, which is known to occur for Tlr7 and Tlr8 (and potentially other boxed genes). Full names of the genes are provided in Fig. 3. PAR, pseudoautosomal region; ΔSry, deletion of Sry gene; Xa, active X chromosome; Xi, inactive X chromosome; XXov, XX chromosomes with ovaries, XXte, XX chromosomes with testes; XYov, XY chromosomes with ovaries; XYte, XY chromosomes with testes; YSry−, Y chromosome lacking Sry and containing translocation of 9 genes from the X chromosome; TgSry, Sry contained on a transgene within an autosome (not depicted in the diagram); Y*, Y*X, and XY* represent variants of the Y chromosome that occur in the XY* model and have the genetic composition illustrated in the diagram. Figure was created with BioRender.com released under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License