Fig. 1

Characterization of female adipose-specific Ghr knockout mice. A: Schematic view of the mouse lines generation. B: Growth curves of female KO and LL mice after 24 weeks of RC feeding (n = 7 mice/group). C: Fat mass of 24-week-old female KO and LL mice (n = 7 mice/group). D: Organ mass of 24-week-old female KO and LL mice (n = 7 mice/group). E-I: Serum GH (E), IGF-1 (F), fasting insulin (G), blood glucose (H) and adiponectin (I) levels of 24-week-old female LL and KO mice (n = 5–9 mice/group). J: Glucose tolerance tests (GTTs) of 24-week-old female KO and LL mice (n = 7 mice/group). K: Insulin tolerance tests (ITTs) of 24-week-old female KO and LL mice (n = 7 mice/group)