Fig. 4

Female offspring of KO mothers are resistant to diet-induced obesity and glucose homeostasis is improved. A: Growth curves of female offspring of KO and LL maternal mice during HF feeding (n = 4–5 mice/group). B: Increase in body weight (24-week vs. 8-week) of female offspring of KO and LL maternal mice (n = 4–5 mice/group). C: Fasting blood glucose levels of female offspring mice fed a high-fat diet for 8 weeks (n = 4–5 mice/group). D and E: GTTs (D) and ITTs (E) results for female offspring mice fed a high-fat diet for 8 weeks (n = 4–5 mice/group). Inset: The area under the curve. F: Fasting blood glucose levels of female offspring mice fed a high-fat diet for 16 weeks (n = 4–5 mice/group). G and H: GTTs (G) and ITTs (H) results for female offspring mice fed a high-fat diet for 16 weeks (n = 4–5 mice/group). Inset: The area under the curve. All the values are presented as the means ± SEMs. The statistical significance was indicated by *p < 0.05, **p < 0.01 and ***p < 0.001.