Fig. 5

Amplification effects on DNAm in cancers. a Proportions of weights on different types of correlation relationships between female and males for each cancer. Perfect correlation is indicated when corr = 1. Partial correlation is represented when 0 < corr < 1. Negative correlation is denoted when corr < 0. Uncorrelated condition is described when corr = 0. b Proportions of weights on different types of magnitude relationships between sexes for nine cancers. "female > male" indicates larger effect sizes in females than in males. "female < male" indicates larger effect sizes in males than in females. "female = male" represents equal effect sizes between sexes. c The difference between the fraction of male-larger effects and the fraction of female-larger effects classified these nine cancer types into female- and male-biased group. The male-biased group is located above the diagonal, while female-biased group is located below the diagonal. d Example of weights on covariance matrices for BLCA, which exhibited the greatest magnitude of DNAm changes in males