Fig. 7
Characterizing the correlations between DNAm and gene expression. a Discovery of eQTMs pairs per sex and per cancer. Left, the number of sample sizes per sex and per cancer (heatmap). Right, the number of eQTMs (Bonferroni-adjust P < 0.05, histogram). The sex-overlapped eQTMs, female-specific eQTMs, and male-specific eQTMs are indicated. b Cancer sharing profile of eQTMs per sex. c Discovery of the detected sex-amplifiers with significantly sex-stratified differential gene expression using eQTM pairs. The directions of correlation are depicted. d Examples of female-amplifiers that were significantly correlated with gene expression of target genes, exhibiting a consistently greater magnitude of gene expression changes in females compared to males. e Examples of male-amplifiers that were significantly correlated with gene expression of target genes, exhibiting a consistently greater magnitude of gene expression changes in males compared to females. *Pbonf < 0.05; **Pbonf < 0.01; ***Pbonf < 0.001. eQTMs methylome and transcriptome correlations