Fig. 1

Sex-dependent miRNA expression in adult mouse hippocampal microglia. A Heatmap depicting microRNA (miRNA) expression profiles from microarray analysis of microglia isolated from the hippocampal tissue pooled from 8-month-old male and female mice. The heatmap highlights 30 miRNAs with differential expression between females and males, with a fold change greater than 2. B and C Summary of male-enriched (B) and female-enriched (C) miRNAs as in (A). Average signal intensities for females (F_Avg Signal) and males (M_Avg Signal), fold change between sexes, and the chromosomal location of each miRNA are shown