Fig. 2

Decreased KMO activity and increased KYNA in the brain of Kmo heterozygous female and male mice. A Brain KMO activity in HET-Kmo^+/– mice is reduced compared to WT-Control mice (Unpaired t test ***P < 0.001, ****P < 0.0001). B Brain KYNA levels in HET-Kmo^+/– mice are increased compared to WT-Control mice (Unpaired t test **P < 0.01, ****P < 0.0001). Data are mean ± SEM. N = 5–7 per group