Fig. 1

UGT deletions significantly impact the metabolic profile of plasma. (A) The study cohort consisted of homozygous reference gene carriers or UGT knockout (KO) individuals (n = 4731) from the genotyped comprehensive CLSA cohort for which metabolomics profiles (n = 1458 metabolites) were assessed. (B) Number of significantly altered metabolites in each UGT KO group relative to the gene-proficient reference group (P < 0.05). Total number of metabolites of lower or higher abundance is given for each UGT KO group. A detailed report on the metabolites affected in each group is available in Supplementary Table 2. C–E. Venn diagrams depicting the number of altered metabolites in the overall and sex-based analyses; (C) UGT2B17 KO, (D) UGT2B28 KO and (E) double KO. F–H. Distribution of altered metabolites within superpathways for each UGT KO group in the overall and sex-based analyses. Results were consistent when limited to postmenopausal women (Supplementary Table 2.1). The numbers above each bar represent the percentage of altered metabolites relative to the total number of metabolites measured in each superpathway