Fig. 4

Non-lipid metabolic pathways that are altered by UGT KO. A. Enrichment analysis of each subclass of metabolites for the overall (O), male (M) and female (F) analyses. Bubble size represents the enrichment score for each UGT KO group. B–D. Relative abundance of significantly altered representative metabolites in each KO group. Results were consistent when limited to postmenopausal women (Supplementary Table 2.1). Boxes represent interquartile range, the median (horizontal bar), and mean (+). Whiskers depict minimum and maximum values. Ref: reference group. *P < 0.05, **P < 0.01, ***P < 0.001