Fig. 5
Association of UGT2B17 KO divergent metabolites with the most common metabolic diseases and chronic conditions. A. Number of metabolites per subpathway significantly associated with diseases. CVD, cardiovascular diseases. B. Odds ratio (OR) and 95% confidence interval (CI) for the core metabolites commonly associated with obesity, hypertension and diabetes. 3α-diol-G, 5α-androstan-3α,17β-diol-17-glucuronide; 11β-ADT-G, 11β-hydroxyandrosterone glucuronide; PC (P-16:0/18:2), 1-(1-enyl-palmitoyl)-2-linoleoyl-glycerophosphocholine (P-16:0/18:2); 3MG carnitine, 3-methylglutarylcarnitine. Associations were significant (Padj<0.05) in a model adjusted for age, smoking and alcohol consumption. The overall analysis was also adjusted for sex. C. Significant associations (Padj<0.05) between the core metabolites and biomarkers related to obesity, diabetes and hypertension. BMI, body mass index; WC, waist circumference; A1C, hemoglobin A1c; HDL, high-density lipoprotein; TGL, triglycerides; DBP, diastolic blood pressure; SBP, systolic blood pressure