Fig. 6
Metabolomic profile of UGT2B28 KO is associated with chronic diseases. A. Number of metabolites per subpathway significantly associated with each disease. B–F. Odds ratio (OR) and 95% confidence interval (CI) for metabolites associated with obesity, hypertension, diabetes, cardiovascular diseases and arthritis. 3β-cholestenoate, 3β-hydroxy-5-cholestenoate; Cys-glutathione-SS, cysteine-glutathione disulfide; 2-HPAA, 2-hydroxyphenylacetate; N-lactoyl-Leu, N-lactoyl-leucine; N-lactoyl-Phe, N-lactoyl-phenylalanine; N-lactoyl-Tyr, N-lactoyl-tyrosine. Associations were significant (Padj<0.05) in a model adjusted for age, smoking and alcohol consumption, and for sex for the overall analysis. In UGT2B28 KO females, after adjusting for these covariates as well as menopausal status and history of HRT use, all metabolites associated with obesity, diabetes, and X-23,644 in arthritis remained significant (Padj<0.05)