Fig. 1
From: ERβ mediates sex-specific protection in the App-NL-G-F mouse model of Alzheimer’s disease
ERβ activation improves cognitive behavior in AppNL−G−F male and female mice. A Treatment regime of AppNL−G−F mice. B Representative image of Y-maze arena. C Percent Y-maze arm alterations and D total number of arm entries of male (left) and female (right) AppNL−G−F mice treated with vehicle or ERβ agonist LY500307 (LY) (n = 7–10). E Diagram showing the fear conditioning paradigm. F Percent context-associated freezing time of male (left) and female (right) AppNL−G−F mice (n = 6–9) in the contextual fear conditioning test. Cued-associated freezing time in the contextual fear conditioning test of G male and H female AppNL−G−F mice before cue (baseline) and upon cue (tone) in a different cage context (n = 6–9). Female mice were either ovariectomized (OVX) or sham operated (Sham). * P < 0.05, ** P < 0.01, *** P < 0.001. Unpaired t-test was used for males and 2-way ANOVA for females followed by uncorrected Fisher’s LSD test for multiple comparisons. Overall significant main effects of treatment or OVX are indicated